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Impact of tryptophan metabolites on bone characteristics.
| Tryptophan Metabolites | Oxidative Stress | BM Adiposity | BMD | BV/TV | Osteogenesis | Osteoclastogenesis |
|---|---|---|---|---|---|---|
| 1. Kyn | 🠕 | 🠕 | 🠗 | 🠗 | 🠗 | 🠕 |
| 2. KYNA | 🠗 | |||||
| 3. 3HKYN | 🠕 | 🠗 | ||||
| 5. 3HAA | 🠕 | |||||
| 6. XA | 🠕 | |||||
| 7. PIA | 🠕 | 🠕 | ||||
| 8. QA | 🠕 | |||||
| 9. NAD+ | 🠗 | 🠕 | * | |||
| 10. GDS | 🠗 | 🠗 | 🠕 | |||
| 11. BDS | 🠕 | 🠕 | 🠗 | |||
| 12. ME | 🠗 | 🠗 | 🠕 |
Summary of the impact of tryptophan metabolism on bone homeostasis. * ADP-ribose inhibits osteoclastogenesis; cyclic ADP-ribose promotes osteoclastogenesis.
