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Immunohistochemical staining for glial fibrillary acidic protein (GFAP) showing retinal neuronal network in normal mice retina in Wfs1-wild-type mice (A,B) and the corresponding representative images of neuronal retinal defects in the Wfs1-mutated mice (C,D). Fewer neurons positive for GFAP can be seen in (C,D). Magnification of 400X. Abbreviations: GFAP: glial fibrillary acidic protein; Wfs1: Wolfram syndrome 1 gene mice.
