Table 1.
Morphometric analysis of the mice retinal thickness and morphology in the Wfs1KO and Wfs1WT mice. Abbreviations: Wfs1KO: Wolfram syndrome 1 gene knockout mice; Wfs1WT: Wolfram syndrome 1 gene wild-type mice; GFAP: glial fibrillary acidic protein.
| Characteristics | Wfs1KO Male Mice | Wfs1WT Male Mice | p-Level * |
|---|---|---|---|
| Analyzed eyeballs/animals | N = 6/N = 3 | N = 6/N = 3 | NA |
| Longitudinal diameter of eye (μm) | 2921 ± 125 | 2868 ± 63 | 0.376 |
| Lateral diameter of eye (μm) | 2616 ± 172 | 2608 ± 111 | 0.927 |
| Retinal thickness (μm) | 235.2 ± 8.0 | 243.7 ± 5.5 | 0.058 |
| Retinal thickness/longitudinal diameter ratio | 0.081 ± 0.003 | 0.085 ± 0.003 | 0.035 |
| Lateral retinal thickness (μm) | 125.8 ± 4.1 | 133.7 ± 11.5 | 0.135 |
| Lateral retinal thickness/lateral diameter ratio | 0.048 ± 0.003 | 0.051 ± 0.003 | 0.112 |
| Intra-retinal neovessels in ganglion cell layer | 4/3 | 0/6 | 0.110 |
| Vessel dilation or microaneurysms | 4/3 | 0/6 | 0.11 |
| GFAP positive cells in inner nuclear layer (cells/100 μm2) | 2.9 ± 0.3 | 3.8 ± 0.4 | 0.042 |
* significant difference according to the nonparametric tests. NA, not applicable.