Table 1.
Demographic and clinical characteristics of the study population.
| Variables | n Patients | Marfan | n Patients | Non Marfan | p-Value | |
|---|---|---|---|---|---|---|
| Age | 20 | 30.5 [17–60] | 20 | 46 [17–55] | 0.025 | w |
| BMI | 20 | 25.1 ± 3.7 | 20 | 26.3 ± 3.4 | 0.316 | t |
| BSA | 20 | 1.9 [1.4–2.4] | 20 | 2 [1.4–2.2] | 0.704 | w |
| Hypertension | 20 | 5 (25%) | 20 | 11 (55%) | 0.105 | f |
| Dyslipidemia | 20 | 1 (5%) | 20 | 5 (25%) | 0.182 | f |
| Diabetes (insulin-dependent) | 20 | 1 (5%) | 20 | 1 (5%) | 1.000 | f |
| Diabetes (not insulin-dependent) | 20 | 0 (0%) | 20 | 1 (5%) | 1.000 | f |
| Smoke | 20 | 6 (30%) | 20 | 10 (50%) | 0.333 | f |
| Obesity | 20 | 1 (5%) | 20 | 2 (10%) | 1.000 | f |
| Peripheral artery disease | 20 | 3 (15%) | 20 | 2 (10%) | 1.000 | f |
| Reoperation | 20 | 1 (5%) | 20 | 0 (0%) | 1.000 | f |
| Chronic Pulmonary Disease | 20 | 0 (0%) | 20 | 1 (5%) | 1.000 | f |
| Creatinine mg/dl | 20 | 0.8 [0.6–1.1] | 20 | 0.8 [0–1.3] | 0.978 | w |
| Cardiovascular Disease Familiarity | 3 (15%) | 10 (50%) | 0.041 | f | ||
| NYHA | 20 | 20 | 0.537 | f | ||
| I | 15 (75%) | 11 (55%) | ||||
| II | 2 (10%) | 5 (25%) | ||||
| III | 2 (10%) | 3 (15%) | ||||
| IV | 1 (5%) | 1 (5%) | ||||
| Atrial Fibrillation | 20 | 0 | 19 | 1 (5.3%) | 0.487 | f |
| EuroScore II | 20 | 0 [0-0.1] | 20 | 0 [0–0.1] | 0.924 | w |
| Left Ventricle telediastolic diameter | 20 | 56.1 ± 6.9 | 20 | 54.3 ± 7.8 | 0.433 | t |
| Left Ventricle telesistolic diameter | 20 | 37.6 ± 5.3 | 20 | 36 ± 7.1 | 0.408 | t |
| Left Ventricle telediastolic volume | 20 | 141.9 ± 28.7 | 20 | 142.2 ± 40.1 | 0.982 | t |
| Left Ventricle telesistolic volume | 20 | 56 [54–90] | 20 | 60 [31–111] | 0.849 | w |
| Ejection Fraction % | 20 | 60 [49–76] | 20 | 60 [45–70] | 0.838 | w |
| Pulmonary artery systolic pressure | 20 | 0 [0–35] | 20 | 25 [19–44] | <0.001 | w |
| Aortic Valve Stenosis | 20 | 2 (10%) | 20 | 4 (20%) | 0.661 | f |
| Aortic Valve Regurgitation | 20 | 2 (10%) | 15 | 13 (86.7%) | <0.001 | f |
| Aortic valve morphology | 20 | 20 | 1.000 | f | ||
| bicuspid | 14 (70%) | 13 (65%) | ||||
| tricuspid | 6 (30%) | 7 (35%) | ||||
| Aortic root diameter (mm) | 17 | 49.5 ± 3.5 | 20 | 42.4 ± 6.8 | 0.001 | ξ |
| Sino-tubular Junction diameter (mm) | 6 | 31.3 ± 17.9 | 3 | 35.7 ± 4 | 0.700 | t |
| Ascending Aorta Diameter (mm) | 10 | 29.8 ± 12.5 | 19 | 44.9 ± 7.4 | 0.001 | t |
| Missense mutation | 12 | 60% | ||||
| Splicing mutation | 8 | 40% |
t = t-test, w = Wilcoxon rank sum test, ƒ = Fisher test, ξ = Welch test.