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Phosphoproteomic analysis of withanolide-treated cells. (A) Experimental design. (B) Summary of quantitative data. (C) Number of phosphopeptides changes induced by WTH and CoA at the named time points. (D–F) CoA and WTH induced changes in kinase activities (D), kinase axes (E) and pathways (F). Z-scores and p-values were calculated for the named cell lines and treatment using the PAGE and Kolmogorov-Smirnoff test, respectively (see Methods for details).
