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. 2020 Sep 22;21(18):6955. doi: 10.3390/ijms21186955

Figure 6.

Figure 6

A model for ribosome pausing near the HCV genome stop codon and NS5B binding to the 3′-end of the viral RNA genome. The HCV 3′region (A) folds back to allow binding of yet incompletely translated NS5B protein to the SL1 of the HCV 3′end RNA (B). When completing NS5B translation (C), NS5B starts and proceeds RNA minus strand synthesis (D). Black triangles, square, diamond, and circle indicate rare codons as in previous figures. The NS5B stop codon is indicated by an asterisk. VR, variable region; 3′X, 3′X region with highly conserved stem-loops (SL) 1, 2, and 3.