Table 3.
Summary of outcomes in in vivo studies comparing FLASH and conventional dose-rate PBT.
| Model | Dose (Gy) | FLASH Dose-Rate (Gy/s) | Outcome | Reference |
|---|---|---|---|---|
| Zebrafish embryo | 0–43 | 100 | No survival difference | [61] |
| Mice (thorax) | 15/17.5/20 | 40 | Normal tissue protection with FLASH | [24] |
| Mice (thorax) | 15/17.5/20 | 40 | Normal tissue protection with FLASH | [25] |
| Mice (abdomen) | 15 | 78 | Normal tissue protection with FLASH | [27] |
| Mice (local intestinal) | 18 | 78 | Normal tissue protection with FLASH | [27] |
| Mice, orthotopic engrafted Lewis lung carcinoma (thorax) | 18 | 40 | Improved tumor control with FLASH, increased T-lymphocyte tumor infiltration | [29] |
| Mice, pancreatic MH641905 flank tumor | 12/15 | 78 | No difference in tumor control | [27] |
| Mice, FaDu head, and neck squamous cell carcinoma transplantation | 17.4 | >109 | No difference in tumor control | [62] |