Table 4.
AD-associated genes in Novo zhonghua database correlation analysis.
| Gene | Alt_case | Ref_case | Alt_control | Ref_control | p value |
|---|---|---|---|---|---|
| ACTA2 | 4 | 194 | 5 | 5649 | 0.00014 |
| FBN1 | 8 | 190 | 99 | 5555 | 0.02789 |
| SLC2A10 | 3 | 195 | 30 | 5624 | 0.09926 |
| ELN | 3 | 195 | 46 | 5608 | 0.2297 |
| MYH11 | 5 | 193 | 87 | 5567 | 0.24114 |
| TGFBR2 | 2 | 196 | 27 | 5627 | 0.25712 |
| COL5A1 | 1 | 197 | 105 | 5549 | 0.26919 |
| NOTCH1 | 2 | 196 | 130 | 5524 | 0.32839 |
| TGFB2 | 1 | 197 | 11 | 5643 | 0.33863 |
| COL3A1 | 2 | 196 | 36 | 5618 | 0.37014 |
| FBN2 | 6 | 192 | 124 | 5530 | 0.4541 |
| PLOD1 | 2 | 196 | 54 | 5600 | 0.71451 |
| COL5A2 | 2 | 196 | 79 | 5575 | 1 |
| MYLK | 2 | 196 | 60 | 5594 | 1 |
Gene: gene name; Alt_case: number of mutated alleles in our 99 cases; Ref_case: number of nonmutated alleles in 99 cases; Alt_control: number of mutated alleles in control 2827 Novo zhonghua cases; Ref_control: number of nonmutated alleles in control 2827 Novo zhonghua cases; p value: p value obtained by Fisher's test between our cases and cases in Novo zhonghua database.