Figure 10.

A model for the mechanism of Hsp70-induced Bmi1 upregulation in the protection of sound conditioning against acute acoustic trauma by directly targeting SOD1 and SOD2 regulated by the FoxO1 signaling pathway. Hsp70/Bmi1-FoxO1-SOD1/SOD2 signaling pathway decreases sensitivity in noise-induced trauma following sound conditioning by controlling mitochondrial function and ROS level in rat's SGN. Meanwhile, based on previous studies, other pathway is also involved in Bmi1 deficiency-induced ROS accumulation, such as the following: Bmi1 deficiency directly leads to p53-mediated repression of antioxidant genes, resulting in increased ROS.