Figure 2.

Baseline systemic inflammation is negatively associated with both CAR T-cell expansion relative to pretreatment TB and the rate of durable responses. (A-C) Peak CAR T-cell expansion and peak CAR T-cell expansion normalized to TB were analyzed by quartile (Q) analyses of proinflammatory and myeloid activation markers. (D-F) Logistic regression analysis evaluating the association of durable response with baseline proinflammatory and myeloid activation markers. Bar graphs show medians per quartile, and Spearman’s correlation was used to calculate R and P values for all bar graphs.