Table 5.
Outcomes by treatment cohort and number of prior lines of therapy
| Outcomes | Alternate | CAR T | P |
|---|---|---|---|
| 2 prior lines | |||
| Total, n | 146 | 32 | |
| CR rate, % | 22 | 56 | <.001 |
| ORR, % | 32 | 75 | <.001 |
| Median OS, mo | 6.5 | 19.3 | .02 |
| Median PFS, mo | 2.3 | 6.4 | .04 |
| 3 prior lines | |||
| Total, n | 59 | 23 | |
| CR rate, % | 8.6 | 52 | <.001 |
| ORR, % | 16 | 74 | <.001 |
| Median OS, mo | 4.7 | Not reached | .001 |
| Median PFS, mo | 1.7 | 12.3 | <.001 |
| 4 prior lines | |||
| Total, n | 26 | 14 | |
| CR rate, % | 8 | 43 | .02 |
| ORR, % | 8 | 64 | <.001 |
| Median OS, mo | 2.9 | 7.0 | .03 |
| Median PFS, mo | 1.4 | 3.0 | .008 |
P values in bold are statistically significant.