Figure 1.

Representative bioluminescent monitoring images of Klebsiella pneumoniae-induced lung infection in mice (n = 6 mice per group). A suspension of a bioluminescent K. pneumoniae strain (3 × 10⁸ colony forming units/ml) was intratracheally inoculated into immunosuppressed mice. The polychromatic bar to the right of the images indicates the bioluminescent intensity and the counts per second (cps) value semi-quantitatively represents the bioluminescent intensity. Mice in group 4 were immunocompetent mice injected with saline prior to lung infection. Mice in group 5 were immunosuppressed mice injected with 50/50 mg/kg cyclophosphamide (CTX) prior to lung infection. Mice in group 6 were immunosuppressed mice injected with 150/100 mg/kg CTX prior to lung infection. Mice were monitored at 0 h, 6 h, 12 h, 24 h and 48 h after lung infection. The colour version of this figure is available at: http://imr.sagepub.com.