Figure 5.

Representative histopathological images of the left lungs (haematoxylin and eosin stained) and lung injury scores of mice in the six groups (n = 6 mice per group). (a) Group 1, immunocompetent mouse, sacrificed at 24 h post-infection; group 2, immunocompetent mouse, sacrificed at 48 h post-infection; group 3, immunosuppressed mouse, injected 50/50 mg/kg cyclophosphamide (CTX), sacrificed at 24 h post-infection; group 4, immunosuppressed mouse, injected 50/50 mg/kg CTX, sacrificed at 48 h post-infection; group 5, immunosuppressed mouse, injected 150/100 mg/kg CTX, sacrificed at 24 h post-infection; group 6, immunosuppressed mouse, injected 150/100 mg/kg CTX, sacrificed at 48 h post-infection. Scar bar 50 µm. (b) Analysis of mouse lung injury scores in the six groups. The categories applied to generate the score were alveolar haemorrhage, alveolar septal congestion, intra-alveolar infiltrates and intra-alveolar fibrin deposition. Data presented as mean ± SD. **P < 0.01, ***P < 0.001, ****P < 0.0001; one-way analysis of variance followed by Dunnett’s test for groups comparisons. The colour version of this figure is available at: http://imr.sagepub.com.