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. 2020 Oct 12;48(10):0300060520962910. doi: 10.1177/0300060520962910

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Effect of CCM on myocardial fibrosis. (a–c) Representative picrosirius red staining of the myocardium in the sham, HF, and CCM groups. Magnification, ×400, scale bar: 50 µm. (d) Percentage of areas of collagen I among the three groups. (e) Percentage of areas of collagen III among the three groups. (f) Comparison of hydroxyproline content among the three groups. Each bar represents the mean ± standard deviation. *P < 0.05 vs. the sham group (n = 5); ^#P < 0.05 vs. the HF group (n = 5).

CVF, collagen volume fraction; HF, heart failure; CCM, cardiac contractility modulation.