. 2020 Sep 30;11:572567. doi: 10.3389/fimmu.2020.572567

Table 2.

The roles of decidual innate lymphoid cell subsets in pregnancy (152–155).

Subset name		Phenotype	Greatest abundance	Key effectors	Roles in the decidua
ILC1	dNK cells	CD56^bright CD16⁻ KIR^++/− CD9⁺ Tbet⁺ Eomes⁺	Early pregnancy	Perforin Granzyme B Granulysin Cytokines	Tolerance Trophoblast invasion Tissue remodeling Antiviral immunity
	Non-cytotoxic ILC1	CD56⁻CD127⁻ CD117⁻Tbet⁺ Eomes-	Early pregnancy	IFN-γ	Defense against intracellular bacteria and parasitic infection Allergy
ILC2		CD56⁻CD127⁺ CD161⁺Tbet⁻	Late pregnancy	IL-4, IL-5, IL-13, IL-22	Tolerance Tissue repair Homeostasis
ILC3	NCR⁺	CD127⁺CD117⁺NCR⁺	Early pregnancy	IL-8, IL-22, GM-CSF	Tissue remodeling Neutrophil recruitment and activation
	NCR⁻	CD127⁺CD117⁺NCR⁻	Early pregnancy	IL-17A, TNFα	Renewal of NCR⁺ population through ILC3 plasticity
	LTi-like	Defined by RORγt expression	Early pregnancy	IL-17A, TNFα	Tissue remodeling Recruitment of other immune cells

dNK cells, decidual natural killer cells; Eomes, eomesodermin; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL-, interleukin-; ILC, innate lymphoid cells; KIR, killer-cell immunoglobulin-like receptors; LTi, lymphoid tissue inducer, NCR, natural cytotoxic receptor; RORγt, RAR-related orphan gamma receptor; T-bet, T-box expressed in T cells; TNF, tumor necrosis factor.