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Mechanisms of T cell response evasion by EBV. EBV interferes with viral epitope processing and reduces MHC molecule expression in infected host cells, induces up-regulation of immune checkpoint molecule PD-L1 and secretes cytokines and chemoattractants that stimulate Treg recruitment and inhibiti anti-viral CD4+ T cell responses by blocking the differentiation of naïve CD4+ T cells to Th1 cells.
