TABLE 1.
Expression of EBV gene products and their functions during lytic phase of infection.
| Lytic phase stage | EBV gene | Function of gene product in productive infection |
| Immediate early | BZLF-1 | Transcriptional activator, essential for lytic infection |
| BRLF-1 | Transcriptional activator, essential for lytic infection | |
| Early | BMRF-1 | Transcriptional activator, viral DNA processivity factor |
| BALF-1 | Viral Bcl-2 homologue, anti-apoptotic, associates with Bax and Bak | |
| BHRF-1 | Viral Bcl-2 homologue, anti-apoptotic, bocks the pro-apoptotic PUMA factor, inhibition of p53-dependent DNA damage response | |
| BALF-3 | Terminase, involved in DNA synthesis and packaging, required for the production of mature virions | |
| BCRF-1 | Viral interleukin-10 (vIL-10), enhances outgrowth of EBV transformed cells | |
| BGLF-5 | Viral exonuclease, participates in viral linear genome synthesis, viral encapsidation, nuclear egress, virus production | |
| Late | BALF-4 | Envelope glycoprotein, required for target cell infection, viral fusion with plasma membrane and endosomal membrane |
| BLLF-1 | Envelope glycoprotein, initiates virion attachment to host B-lymphocyte cell, leading to virus entry |