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. 2020 Sep 29;8:e9946. doi: 10.7717/peerj.9946

Figure 3. Expression verification of six hub genes.

Figure 3

(A) Hub genes expression in multiple types of human cancers from Oncomine database. Red: up-regulated; blue: down-regulated. (B–K) Immunohistochemical staining analysis of hub genes in breast cancer based on the Human Protein Atlas. (B) Protein levels of RRM2 in normal tissue (staining: not detected; intensity: negative; quantity: none). (C) Protein levels of RRM2 in tumor tissue (staining: low; intensity: moderate; quantity: < 25%). (D) Protein levels of CDC20 in normal tissue (staining: not detected; intensity: negative; quantity: none). (E) Protein levels of CDC20 in tumor tissue (staining: high; intensity: strong; quantity: 75%–25%). (F) Protein levels of CCNB2 in normal tissue (staining: not detected; intensity: negative; quantity: none). (G) Protein levels of CCNB2 in tumor tissue (staining: medium; intensity: moderate; quantity: 75%–25%). (H) Protein levels of CDK1 in normal tissue (staining: not detected; intensity: negative; quantity: none). (I) Protein levels of CDK1 in tumor tissue (staining: high; intensity: strong; quantity: 75%–25%). (J) Protein levels of CCNA2 in normal tissue (staining: not detected; intensity: negative; quantity: none). (K) Protein levels of CCNA2 in tumor tissue (staining: medium; intensity: strong; quantity: < 25%). There were no related immunohistochemical samples of BUB1B in the database.