Table 2. Antineoplastic drugs targeting hub genes based on the DGIdb database.
| Target | Drug | Type | Sources | PMIDs | Score |
|---|---|---|---|---|---|
| RRM2 | CLADRIBINE | inhibitor | DrugBank | 17852710 16316309 19576186 9923554 19715446 |
6 |
| GALLIUM NITRATE | inhibitor | ChemblInteractions DrugBank | 12776257 1335254 15651176 |
5 | |
| MOTEXAFIN GADOLINIUM | inhibitor | TdgClinicalTrial DrugBank TTD | – | 3 | |
| HYDROXYUREA | inhibitor | GuideToPharmacologyInteractions ChemblInteractions | – | 2 | |
| CLOFARABINE | inhibitor | GuideToPharmacologyInteractions ChemblInteractions | – | 2 | |
| GEMCITABINE | inhibitor | ClearityFoundationClinicalTrial GuideToPharmacologyInteractions | – | 2 | |
| FLUDARABINE PHOSPHATE | inhibitor | ChemblInteractions | – | 1 | |
| TRIAPINE | – | TdgClinicalTrial | – | 1 | |
| FLUDARABINE | inhibitor | GuideToPharmacologyInteractions | – | 1 | |
| CDK1 | DINACICLIB | inhibitor | MyCancerGenome ClearityFoundationClinicalTrial GuideToPharmacologyInteractions ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial | – | 6 |
| ALVOCIDIB | inhibitor | MyCancerGenome TdgClinicalTrial ChemblInteractions DrugBank | 11752352 | 5 | |
| Roniciclib | inhibitor | GuideToPharmacologyInteractions ChemblInteractions CancerCommons | – | 3 | |
| AT-7519 | inhibitor | GuideToPharmacologyInteractions ChemblInteractions DrugBank | – | 3 | |
| AZD-5438 | inhibitor | GuideToPharmacologyInteractions ChemblInteractions | – | 2 | |
| TG-02 | inhibitor | GuideToPharmacologyInteractions ChemblInteractions | – | 2 | |
| CHEMBL1236539 | inhibitor | GuideToPharmacologyInteractions | – | 1 | |
| RG-547 | inhibitor | ChemblInteractions | – | 1 | |
| SELICICLIB | inhibitor | ChemblInteractions | – | 1 | |
| CCNA2 | SURAMIN | – | NCI | 10208280 | 2 |
| CORDYCEPIN | – | NCI | 11566717 | 2 | |
| GENISTEIN | – | NCI | 9664138 | 2 |