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. 2020 Sep 25;11:571143. doi: 10.3389/fphar.2020.571143

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Copyright © 2020 Zhang, Chen, Ni, Wang, Zheng, Zhang, Xu and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis of genesets in HCC tumor tissues. A microarray dataset (GSE102081) of HCC tumor tissues and normal liver (NL) tissues was analyzed using the GSEA tool. (A–C) The enrichment indexes of three genesets are shown in (A) (sulfur amino acid metabolism), (B) (cysteine and methionine metabolism), and (C) (vitamin B₆ binding activity), respectively. The genesets were considered to be significantly enriched at NES (normalized enrichment score) >1, Nom P (nominal p-value) <0.05, and FDR q-value <0.25. (D–F) Heatmaps of the enriched genes in (A–C) were created to display their relative expression.