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. 2020 Sep 25;11:571143. doi: 10.3389/fphar.2020.571143

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Copyright © 2020 Zhang, Chen, Ni, Wang, Zheng, Zhang, Xu and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the interaction among the leading-edge genes. (A) The ownership and relative expression of the leading-edge genes from three genesets (sulfur amino acid metabolism GO set, cysteine and methionine metabolism KEGG set, and vitamin B₆ binding activity GO set) were presented through a chord diagram, which was drawn using the GOPlot R package. (B) The interaction of the genes was analyzed with the STRING online tool. The PPI network was constructed and the interaction degrees were calculated with Cytoscape 3.7 software.