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. 2020 Sep 25;11:571143. doi: 10.3389/fphar.2020.571143

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Copyright © 2020 Zhang, Chen, Ni, Wang, Zheng, Zhang, Xu and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–I) Expression of the hub genes between 160 normal liver tissues (50 samples of TCGA_LIHC cohort and 110 samples in GTEx dataset) and 368 HCC tumor tissues of TCGA_LIHC cohort were observed. Data are shown as median ± quartile, *P < 0.001 vs. Normal liver tissues. (J–R) Analysis of the survival rate of HCC patients in TCGA_LIHC database between high expression (red lines) and low expression (blue lines) of the hub genes. The number of patients in either group and the Log-rank test’s P are shown in each panel.