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. 2020 Sep 25;11:571143. doi: 10.3389/fphar.2020.571143

Figure 8.

Figure 8

Development of a sulfane sulfur donor-specific to tumor tissues. (A) With TCGA cohort, effects of SLC7A11 on HCC patient survival between high (red line) and low (blue line) expression groups were examined using Log-rank test. (B) Analysis of TCGA cohort and Cancer Cell Line Encyclopedia for SLC7A11 expression in HCC patient tissues and tumor cell lines, respectively. (C) Mechanism underlying sulfane sulfur generation from PSCP. (D) The generated sulfane sulfur in PBS buffer was measured with a spectrophotometer. (E) After treatment of SNU398 cells with 200 μM PSCP for different times, intracellular sulfane sulfur was observed with SSP4 staining followed by photofluorography, and the cell nuclei were labeled using Hoechst 33324 staining.