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. 2020 Sep 25;11:571143. doi: 10.3389/fphar.2020.571143

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Copyright © 2020 Zhang, Chen, Ni, Wang, Zheng, Zhang, Xu and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Controllable sulfane sulfur compounds-mediated inhibition of cell viability. HCC SNU398 cells were treated with esterase-triggered sulfane sulfur donor 1 (A), 3 (C), 5 (E), or 7 (G), their control compounds 2 (B), 4 (D), 6 (F), or 8 (H), as well as 9 (I), which does not generate sulfane sulfur. After 48 h, the cell viability was tested with CCK-8 assay. (J) Sulfane sulfur generated from the 1, 3, 5, and 7 was measured at 1 and 12 h with a fluorescence probe SSP4. Data are expressed as mean ± SD of four independent experiments. *P < 0.05, ^** P < 0.01 vs. Control group.