Table 1.
Baseline Characteristics of Patients Undergoing Kidney Transplant at the University of Alabama at Birmingham, 2007-2015.
| Characteristic | Total | DAA | Non-DAA | P-value |
|---|---|---|---|---|
| N=59 | n=29 | n=30 | ||
| Event, n (%) | — | |||
| Graft failure | 11 (19) | 2 (7) | 9 (30) | |
| Death | 8 (13) | 2 (7) | 6 (20) | |
| None | 40 (68) | 25 (86) | 15 (50) | |
| Age (as of transplant), years, mean (SD) | 55 (8) | 56 (9) | 54 (8) | 0.47a |
| Sex, n (%) | 0.85b | |||
| Male | 40 (68) | 20 (69) | 20 (67) | |
| Female | 19 (32) | 9 (31) | 10 (33) | |
| Race, n (%) | 0.27c | |||
| African American | 43 (73) | 23 (79) | 20 (67) | |
| Caucasian | 16 (27) | 6 (21) | 10 (33) | |
| Serum creatinine (mg/dL), median (Q1, Q3) | 1.4 (1.0, 1.6) | 1.5 (1.2, 1.6) | 1.3 (1.0, 1.7) | 0.60d |
| Protein:Creatinine ratio, median (Q1, Q3) | 0.5 (0.3, 0.8) | 0.6 (0.4, 0.8) | 0.4 (0.2, 0.9) | 0.23d |
| eGFRe (mL/min/1.73m2), median (Q1, Q3) | 59 (50, 74) | 59 (54, 68) | 61 (44, 89) | 0.96d |
| Donor Type, n (%) | 1.00c | |||
| Deceased | 49 (83) | 24 (83) | 25 (83) | |
| Living unrelated | 6 (10) | 3 (10) | 3 (10) | |
| Living related | 4 (7) | 2 (7) | 2 (7) | |
| Taking ACEi/ARB, n (%) | 35 (59) | 20 (69) | 15 (50) | 0.70b |
| Year of transplant | <0.01b | |||
| 2007–2009 | 16 | 5 (17) | 11 (37) | |
| 2010–2012 | 23 | 8 (28) | 15 (50) | |
| 2013–2015 | 20 | 16 (55) | 4 (13) | |
| Post-transplant follow-up time (years), median (Q1, Q3) | 4.6 (3.2, 6.3) | 4.7 (3.6, 6.9) | 4.2 (3.2, 6.2) | 0.53d |
ACEi=angiotensin-converting enzyme inhibitor; ARB=angiotensin II receptor blocker; DAA=direct acting antiviral; eGFR=estimated glomerular filtration rate; Q1=first quartile; Q3=third quartile; SD=standard deviation.
NOTE: Percentages have been rounded.
a
Unpaired t-test.
b
Chi-square test.
c
Fisher's exact test.
d
Wilcoxon rank-sum test.
e
Calculated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula which utilizes age, sex, and race.[20]