Table 2.
Cox Proportional Hazard Regression Analyses Examining Characteristics Associated With Graft Failure or Death in Kidney Transplant Recipients at the University of Alabama at Birmingham, 2007-2017.
| Characteristic | Univariate analysis | Multivariate analyses (N=59) | ||||||
|---|---|---|---|---|---|---|---|---|
| Crude HR (95% CI) | P-value | Adjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | P-value | |
| A. Outcome of interest | ||||||||
| Group: DAA vs Non-DAAa | 0.19 (0.06 – 0.66) | 0.01 | 0.30 (0.08 – 1.10) | 0.07 | 0.28 (0.07 – 1.07) | 0.06 | 0.32 (0.08 – 1.21) | 0.09 |
| B. Confounders | ||||||||
| Age (per 1-year increase) | 0.98 (0.92 – 1.04) | 0.51 | 0.97 (0.90 – 1.05) | 0.49 | 0.97 (0.90 – 1.04) | 0.40 | 0.98 (0.91 – 1.06) | 0.58 |
| Sex: Male vs Femalea | 1.16 (0.41 – 3.29) | 0.78 | 1.46 (0.42 – 5.14) | 0.56 | 1.31 (0.38 – 4.47) | 0.67 | 1.47 (0.41 – 5.29) | 0.56 |
| Race: African American vs Whitea | 0.69 (0.26 – 1.83) | 0.46 | 0.78 (0.24 – 2.54) | 0.68 | 0.81 (0.26 – 2.50) | 0.72 | 0.66 (0.20 – 2.18) | 0.49 |
| Proteinuria Metrics (per unit increase) | ||||||||
| Time-varying | 1.51 (1.27 – 1.80) | <0.001 | 1.40 (1.16 – 1.70) | 0.001 | -- | -- | -- | -- |
| Time-averaged | 2.16 (1.40 – 3.31) | 0.001 | -- | -- | 1.69 (1.04 – 2.74) | 0.04 | -- | -- |
| Time-varying cumulative | 2.54 (1.67 – 3.87) | <0.001 | -- | -- | -- | -- | 2.05 (1.28 – 3.29) | 0.003 |
CI=confidence interval; DAA=direct acting antiviral; HR=hazard ratio; P/C: Protein/Creatinine.
a
Reference category.