Fig 3. Effect of PT1 on downstream targets involved in mitochondrial biogenesis and oxidative stress.

SURF1-deficient patient fibroblasts were treated with PT1 or DMSO (vehicle) for 24 hours and expression of PGC-1 and catalase/SOD2 RNA was evaluated by qPCR (n = 3). Results are normalized to actin. Asterisks represent statistical significance (*p<0.05).