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. 2020 Oct 2;16(10):e1008882. doi: 10.1371/journal.ppat.1008882

Table 4. Molecular interactions between key residues constituting the Fab 4B3:fHbp v1 epitope.

fHbp v1 huFab 4B3 CDR Bond type
F141
F141
S31
Y32
H1
H1
Van der Waals
Van der Waals
D142 S31 H1 hydrogen bond
E146
E146
N52
S54
H2
H2
hydrogen bond
hydrogen bond
R149 D93 L3 salt bridge
D171 F33 L1 Van der Waals
A173
A173
A174
R102
N99
R102
H3
H3
H3
hydrogen bond
hydrogen bond
Van der Waals
K175
K175
S31
N99
H1
H3
hydrogen bond
hydrogen bond
Q176
Q176
Q176
Q176
Y92
Y92
P32
R102
L3
L3
L1
H3
hydrogen bond,
Van der Waals
Van der Waals
hydrogen bond
A195 T54 L2 hydrogen bond
D197
D197
R102
Y50
H3
L2
salt bridge
hydrogen bond
K199 T57 L2 hydrogen bond
Q216 R64 - hydrogen bond
R204 P28 H1 Van der Waals
E218 R55 L2 salt bridge