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. 2020 Jan 16;105(9):2250–2261. doi: 10.3324/haematol.2018.205047

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Copyright© 2020 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 1. — Global downregulation of miRNA expression profile in rheumatoid arthritis neutrophils. (A) Forty-one miRNA altered in neutrophils from PB-RA patients compared to neutrophils from PB-HD using a fold change cut-off >5. (B) Thirty-four miRNA more reduced in RA synovial neutrophils compared to its paired PB sample (fold change cut-off >2). (C) Heat-map of the differentially expressed miRNA profile in PB-HD, PB-RA and SF-RA. (D) Functional classification of the altered miRNA using Ingenuity Pathway Analysis (IPA, QIAGEN Redwood City, CA, USA; https://analysis.ingenuity.com). The analysis included only the functions and pathways with average IPA score >2 indicated as –log (P-value). Threshold bar indicates the cut-off point of significance (P>0.05), using Fisher’s exact test. miRNA: microRNA; RA: rheumatoid arthritis; PB: peripheral blood; HD: healthy donor; SF: synovial fluid.