Table 1. Susceptibility profile of Sporothrix isolates to MMV675968, MMV102872, and iodoquinol.
| Isolates | Itraconazole | MMV675968 | MMV102872 | MMV002817 | ||||
|---|---|---|---|---|---|---|---|---|
| (Iodoquinol) | ||||||||
| S. brasiliensis | IC50 | IC80 | IC50 | IC80 | IC50 | IC80 | IC50 | IC80 |
| Reference isolate | ||||||||
| CBS133006 | 0.03 | 0.25 | 0.25 | 0.5 | 0.25 | 0.5 | 0.25 | 0.5 |
| Human isolates | ||||||||
| B972 | ND | 0.25 | 0.5 | 1 | 0.25 | 0.5 | 0.25 | 0.5 |
| HE06 | ND | 0.25 | 0.125 | 0.5 | 0.125 | 0.25 | 0.25 | 0.5 |
| Feline-borne isolates | ||||||||
| Ss53 | 0.25 | 0.5 | 0.06 | 0.25 | 0.125 | 0.25 | 0.25 | 0.5 |
| Ss245 | 0.06 | 0.25 | 0.125 | 0.5 | 0.125 | 0.25 | 0.25 | 0.5 |
| Median | 0.06 | 0.25 | 0.125 | 0.5 | 0.125 | 0.25 | 0.25 | 0.5 |
| S. schenckii | IC50 | IC80 | IC50 | IC80 | IC50 | IC80 | IC50 | IC80 |
| Reference isolate | ||||||||
| ATCC32286 | 0.125 | 0.25 | 0.03 | 0.125 | ND | 0.25 | 0.5 | 1 |
| Human isolates | ||||||||
| Ss22 | 0.125 | 0.25 | >1 | >1 | 0.25 | 0.5 | 0.5 | 1 |
| Ss42 | ND | 0.25 | ND | 1 | ND | 0.25 | 0.25 | 1 |
| Ss73 | 0.06 | 0.25 | 1 | >1 | 0.125 | 0.25 | 0.25 | 0.5 |
| Ss110 | 0.03 | 0.125 | 0.5 | 1 | 0.125 | 0.25 | 0.25 | 0.5 |
| Median | 0.09 | 0.25 | 0.5 | 1 | 0.125 | 0.25 | 0.25 | 1 |
Minimum inhibitory concentration of different human and feline isolates of S. schenckii and S. brasiliensis to MMV675968, MMV102872, and Iodoquinol, compared with itraconazole.
All values are expressed in μM.
IC50, concentration that inhibits 50% of fungal growth. IC80, concentration that inhibits 80% of fungal growth.
ND, Not determined due to the detection limit of the microdilution technique.