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| Compounds | IC80 medians (μM) | Cytotoxicity against LLC-MK2 cells | Selectivity Indexa | ||
|---|---|---|---|---|---|
| S. brasiliensis | S. schenckii | CC50 (μM) | S. brasiliensis | S. schenckii | |
| MMV102872 | 0.25 | 0.25 | 8.7 | 34.8 | 34.8 |
| MMV002817 (iodoquinol) | 0.5 | 1 | 5 | 10 | 5 |
Cytotoxicity to mammalian cells in vitro and selectivity of MMV102872 and iodoquinol towards Sporothrix brasiliensis and Sporothrix schenckii cells.
a Selectivity index (SI) was defined as SI = CC50/IC80 median.
