Table 4. New compounds with anti-Sporothrix activity.

Compound	Class	Known antimicrobial activity	Described in this work	Mechanism of action
MMV676477	pyrimidinone-pyrazole	Mycobacterium tuberculosis [13]	S. brasiliensis	tyrosine kinase inhibitor [13]
MMV658988	pyrimidine	Trypanosoma and Leishmania species [13]	S. brasiliensis	methionine aminopeptidases inhibitor [13]
MMV687807	hydroxybenzamide	Mycobacterium tuberculosis, Candida albicans [13, 14]	S. brasiliensis	disruption of the mitochondrial proton gradient [13]
MMV675968	quinazoline	Toxoplasma gondii, Cryptosporidium parvum, Pneumocystis jrovecii, Candida albicans [13, 14]	S. schenckii, S. brasiliensis	dihydrofolate reductase inhibitor [13]
MMV102872	oxadiazole	Mycobacterium tuberculosis, Staphylococcus aureus, Candida auris [13, 16]	S. schenckii, S. brasiliensis	unknown

Summary of chemical and biological information of five new compounds with antifungal activity against Sporothrix spp. described in this study.