Table 4.
Observed and predicted value of encapsulation efficiency (Y1), particle size (Y2) and zeta potential (Y3) of formulations in the Box-Behnken design
| Sample | EE, % (Y1) | Zeta potential, mV (Y2) | Particle size, nm (Y3) | PDI | |||
|---|---|---|---|---|---|---|---|
| Observed | Predicted | Observed | Predicted | Observed | Predicted | ||
| PALN1 | 83.81 ± 1.93 | 84.84 | 37.70 ± 1.16 | 37.19 | 187.7 ± 3.75 | 186.09 | 0.238 ± 0.01 |
| PALN2 | 82.15 ± 6.26 | 81.07 | 48.33 ± 1.93 | 50.39 | 264.8 ± 12.21 | 254.17 | 0.429 ± 0.12 |
| PALN3 | 77.28 ± 0.58 | 78.00 | 43.73 ± 5.78 | 44.00 | 177.7 ± 5.23 | 180.51 | 0.216 ± 0.01 |
| PALN4 | 83.44 ± 2.47 | 82.77 | 35.03 ± 1.76 | 33.20 | 231.7 ± 6.32 | 241.17 | 0.228 ± 0.02 |
| PALN5 | 74.17 ± 6.10 | 72.42 | 31.37 ± 1.48 | 31.60 | 187.9 ± 9.56 | 186.76 | 0.243 ± 0.01 |
| PALN6 | 68.45 ± 1.79 | 68.81 | 50.47 ± 1.65 | 48.13 | 186.8 ± 8.98 | 194.69 | 0.232 ± 0.02 |
| PALN7 | 70.17 ± 9.14 | 71.92 | 42.07 ± 1.21 | 41.83 | 254.8 ± 15.45 | 256.00 | 0.237 ± 0.00 |
| PALN8 | 84.72 ± 1.90 | 85.44 | 25.47 ± 1.33 | 28.09 | 156.4 ± 8.98 | 162.83 | 0.314 ± 0.01 |
| PALN9 | 86.67 ± 3.27 | 85.44 | 31.17 ± 1.33 | 28.09 | 178.7 ± 10.54 | 162.87 | 0.179 ± 0.03 |
| PALN10 | 84.67 ± 3.56 | 85.44 | 27.63 ± 2.94 | 28.09 | 166.1 ± 3.65 | 162.87 | 0.244 ± 0.01 |
| PALN11 | 83.97 ± 1.52 | 83.61 | 21.30 ± 2.48 | 23.63 | 198.1 ± 4.78 | 190.29 | 0.167 ± 0.02 |
| PALN12 | 83.57 ± 2.03 | 84.64 | 20.77 ± 5.59 | 18.70 | 240.2 ± 4.56 | 250.82 | 0.208 ± 0.03 |
| PALN13 | 74.13 ± 4.69 | 73.10 | 39.73 ± 1.60 | 40.24 | 254.7 ± 16.87 | 256.30 | 0.347 ± 0.07 |
| PALN14 | 70.86 ± 3.61 | 71.53 | 24.20 ± 1.56 | 26.02 | 251.5 ± 24.56 | 242.08 | 0.360 ± 0.07 |
| PALN15 | 81.77 ± 6.41 | 81.06 | 22.83 ± 2.28 | 22.55 | 249.2 ± 16.87 | 246.42 | 0.344 ± 0.03 |
| PALN16 | 86.09 ± 2.93 | 85.44 | 28.49 ± 1.76 | 28.10 | 157.5 ± 3.45 | 162.83 | 0.263 ± 0.01 |
| PALN17 | 85.06 ± 2.88 | 85.44 | 27.69 ± 1.97 | 28.10 | 155.3 ± 7.65 | 162.82 | 0.228 ± 0.02 |