Table 5.

Statistical Analysis Results of Entrapment Efficiency, Particle Size, and Zeta Potential

Parameter	Drug EE (%)		Particle size (nm)		Zeta potential (mV)
	Coefficient	p value	Coefficient	p value	Coefficient	p value
Intercept	85.4405	< 0.0001*	162.826	< 0.0001*	28.0896	< 0.0001*
X1	3.5735	0.0003*	16.2333	0.0054*	− 3.5675	0.0050*
X2	− 3.8271	0.0002*	18.3916	0.0028*	8.6821	< 0.0001*
X3	− 2.0429	0.0064*	16.7166	0.0047*	− 7.1571	< 0.0001*
X1X2	− 2.0193	0.0315*	14.4667	0.0410*	0.4175	0.7481
X1X3	1.1877	0.1588	− 14.0668	0.0454*	1.8325	0.1860
X2X3	− 1.9454	0.0363*	− 15.65	0.0305*	2.0833	0.1395
X12	− 6.9129	< 0.0001*	17.3868	0.0178*	1.5143	0.2538
X22	− 4.3391	0.0006*	26.7035	0.0021*	6.6986	0.0009*
X32	− 0.1888	0.8044	47.3201	< 0.0001*	1.8436	0.1739

*p value less than 0.05