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. 2020 Oct 14;21(7):285. doi: 10.1208/s12249-020-01810-0

Table 7.

Coefficient of Determination r2 and Releasing Model Constant K for Drug Releasing Models

Model pH 1.2 pH 6.4
Coefficient of determination, r2 Release model constant, K Coefficient of determination, r2 Release model constant, K
Zero order 0.6184 3.1424 0.5605 3.0729
First order 0.9339 0.2588 0.7999 1.3440
Higuchi model 0.9341 25.4563 0.9199 26.5229
Korsmeyer-Peppas model 0.3101 18.6351 0.2953 19.8312
Hixson-Crowell model 0.0053 0.0131 0.0032 0.0100

The italicized is done to show the Nanoparticle release model is folloing Higuchi release model. It is done just to make it more visible