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ARQ531 affects BTK, MYC and MYB in acute myeloid leukemia cells. (A) BTK, MYC, MYB, and especially their simultaneous silencing considerably reduced viability of HL60 cells as measured by Trypan blue staining. The mean of triplicate experiments are shown. (B, C) Triple BTK/MYC/MYB-silenced HL60 cells demonstrate diminished phosphorylation of ERK and PARP full-length form compared with cells depleted either transiently (B) or stably (C) of each gene, individually.
