Table 2.

Urine electrolytes/creatinine ratio in salt-sensitive rats during chronic opioid treatment within 14 d on HS.

	NS	NS
Potassium	8.5 ± 2	15 ± 2
Sodium	33 ± 5	23 ± 2
Calcium	0.24 ± 0.04	0.26 ± 0.03
Chloride	44 ± 8	32 ± 3
	7DHS+Vehicle	7DHS+BRL
Potassium	19 ± 3	16 ± 1
Sodium	437 ± 41	327 ± 17*
Calcium	3.2 ± 0.5	2.9 ± 0.2
Chloride	402 ± 34	310 ± 15*
	14DHS+Vehicle	14DHS+BRL
Potassium	19 ± 1	15 ± 1*
Sodium	372 ± 30	255 ± 9*
Calcium	2.9 ± 0.2	2.1 ± 0.1*
Chloride	323 ± 24	241 ± 9*

κ-OR agonist treated rats (1.5 mg/kg BRL 52537). NS (0.4% NaCl); 7DHS, 14DHS – 7 d and 14 d on HS (8% NaCl), respectively (n ≥ 5 rat per group; t test *P < 0.05, BRL- versus vehicle-treated rats on the same day of treatment).