Figure 4. NRTN reduces MMP1 and MMP3 production from macrophages.

(A, B) Representative Western blot (A) and densitometry analysis of MMP3 (B) in human lung macrophages stimulated with polyI:C (10 μg/ml) ± NRTN (100 ng/ml) for 24 h (n = 3). (C, D, E) Representative Western blot (C) and densitometry analysis of MMP1 (D) or MMP3 (E) protein expression in PMA-treated THP-1 macrophages stimulated with AD80 (0.5 μM) ± NRTN (100 ng/ml) for 24 h (n = 3–7). Densitometry analysis of MMP1 and MMP3 is expressed relative to β-actin. Data information: Data are shown as mean ± SEM from three independent experiments. (B, D, E) *P < 0.05; Student’s paired two-tailed t test (B, D, E).

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