Table 1.

Fold change (log₂) and NDM-1 inhibitor concentrations of peptides from SLAY

						MBC (μM)a, b
Peptide	Sequence	Charge	Hydrophobicity	Fold change (log2)	P value	Ec W3110 NDM-1	Kp NIH1 NDM-1	Ecl ATCC13047 NDM-1
P1	AFRPIPTHSC	1.026	−0.08	−4.26	<4.57e−118	8	32	32
P2	YNYSYIITRS	0.995	−0.52	−3.33	<1.50e−84	128	32	≥128
P3	PTTVHIIYRI	1.088	0.57	−3.88	<2.24e−73	16	16	64
P4	ASVTWLLYAM	−0.002	1.36	−2.83	<3.75e−52	128	128	≥128
P5	LRCLMLKFPI	1.935	1.31	−2.87	<3.62e−41	8	4	4
P6	CLRPSIISRA	1.936	0.49	−3.07	<2.24e−26	32	≥128	≥128
P7	WRYQWTILFI	0.997	0.38	−3.91	<1.81e−25	16	≥128	≥128
P8	FCIRLATYVI	0.935	1.76	−2.68	<2.02e−07	8	≤4	64
P9	PGHRVSCWLS	1.026	−0.17	−2.17	<5.36e−06	≤4	≤4	32

Ec, E. coli; Kp, Klebsiella pneumoniae; Ecl, Enterobacter cloacae.

^aMBCs were determined as the lowest concentration of peptide that results in at least 99.90% killing of the initial inoculums. Data are representative of three independent experiments.

^bAll MBCs were determined with 4 mg/L of meropenem.