Table 2.

Clinical characteristics, treatments and outcomes pneumothorax.

	Case 1	Case 2	Case 3	Case 4	Case 5
Sex	Male	Male	Male	Male	Male
Age, years	79	56	54	69	63
Smoking history	No	No	No	No	No
Chronic lung diseases	No	No	No	No	No
Description of air leaks
Side of PTa	Right	Right	Bilateral	Right	Bilateral
SEb	No	No	No	Yes	No
PDc	No	No	No	Yes	No
Smoking history	No	No	No	No	No
Chronic lung diseases	No	No	No	No	No
RR (breaths /min)	24	10	32	35	34
Arterial blood gas tests before air leaks
pH	7.32	7.36	7.44	7.43	7.46
FiO2	90%	50%+VV-ECMO	37%	70%	55%
PO2/FiO2, mmHg	129	NA	192	110	131
PO2, mmHg	116	72	71	77	72
PCO2, mmHg	76	40	38	72	42
Severity of ARDS	moderate	severe	moderate	moderate	moderate
Paradoxical thoracoabdominal motion	Yes	No	No	Yes	Yes
Mechanical ventilation before air leaks	IMV	IMV+VV-ECMO	NIV+IMV (terminated)	IMV	NIV
Ventilation parameters
VTd, ml/kg	5.8	5	NA	5.5	NA
PEEPe, cmH2O	12	12	NA	8	5
IPAPf, cmH2O	24	25	NA	22	15
Pplatg, cmH2O	<30	<30	NA	<30	NA
Neuromuscular blockers	Yes (decreasing in dose)	Yes	No	Yes (decreasing in dose)	No
Recruitment maneuver	No	Yes	No	No	No
Lung-protective ventilation	Yes	Yes	No	Yes	Yes
ECMO	No	Yes	No	No	No
Days of CT before PT	17	22/10	25/0	37 /27	11/6
CT features
Ground-glass opacity	Yes	Yes/ Yes	Yes /Yes	Yes /Yes	Yes /Yes
Consolidation	Yes	No/ Yes	No /Yes	No /No	No /Yes
Fibrosis	No	No /No	No /Yes	No /No	No/No
Pulmonary cysts	Yes	No /No	No/ Yes	No /No	No /No
Emphysema	Yes	No /No	No/ Yes	No /No	No /No
From dyspnea to occurence of air leaks, days	21	21	28	40	15
From mechanical ventilation to occurence of air leaks, days	18	20	18	37	5
Chest drainage	Yes	No	No	Yes	Yes (Bilateral)
ECMO	Yes	Yes	No	No	No
Pneumothorax resolved	Yes	Yes	Yes	No	No
Virus eliminated	Yes	Yes	Yes	Yes	No
Outcome	Died	Died	Alive	Died	Died
From occurrence of pneumothora to death, days	11	15	NA	7	4
Length of hospital stay, days	29	38	42	44	13

^aPT= pneumothorax,

^bSE= subcutaneous emphysema,

^cPD= pneumomediastinum,

^dV_T = tidal volume,

^ePEEP= positive end-expiratory pressure

^fIPAP= inspiratory positive airway pressure,

^gP_plat = end-inspiratory pressures.