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. 2020 Oct 14;13:138. doi: 10.1186/s13041-020-00679-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Comparison of the transduction efficiency between rAAV9-Retro and rAAV2-Retro injected into the VTA. A, B rAAV2-Retro-CaMKIIa-EGFP and rAAV9-Retro-CaMKIIa-EGFP viruses can efficiently infect neurons when injected into the VTA sites. C–J The two viruses can infect the same upstream brain regions, including the PFC, MO, MSC and MRN. k Comparison of the total number of neurons projecting into the VTA using rAAV9-Retro and rAAV2-Retro. The data are shown as means ± SEM. Statistical significance of differences was set at P < 0.05. No statistical difference was found in the total number of neurons projecting into the VTA (10,770 ± 1394 for AAV2-Retro; 10,278 ± 1957 for AAV9-Retro. P = 0.8477). Scale bars = 200 μm for Fig A-B; Scale bars = 100 μm for figure C–J. VTA: ventral tegmental area; PFC: prefrontal cortex; MO: somatomotor areas; MSC: medial septal complex; MRN: midbrain reticular nucleus