Figure 4:

Three strategies for population-based newborn screening and surveillance follow-up. The models are termed “Classic”, “Simple Adaptive”, and “Advanced Adaptive”. A flow chart for each model is shown in panels a, b and c, respectively. The two adaptive models use the 3-variable T1D CRS to dynamically define the follow-up schedule for each individual in the cohort. Panels d, e and f show the proportion of children remaining under follow-up in each respective scenario using cohort simulations on TEDDY data (n=7,798).

*Risk is recalculated annually during the first 4 years life, then every 2 years thereafter.

**Close follow-up is quarterly to age 3, then biannually to age 6, then annually to age 8.

Reduced follow-up is annually to age 4 and then every two years.