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. Author manuscript; available in PMC: 2021 Feb 7.
Published in final edited form as: Nat Med. 2020 Aug 7;26(8):1247–1255. doi: 10.1038/s41591-020-0930-4

Extended Data Fig. 3. Family history adds predictive power to the T1D GRS2.

Extended Data Fig. 3

T1D GRS2 alone (a) is compared to T1D GRS2 + FH (b) at nine different landmark scoring ages and over four different horizon times. Although 95% confidence intervals always overlapped, among 34 total combinations, T1D GRS2 + FH gave a larger AUC ROC in 24 of these combinations. Results were similar in 9 combinations, and in only one instance was T1D GRS2 better. T1D GRS2 + FH superiority was greatest at landmarks ≤3 years of age. The number of children at each landmark age were 7798 (birth), 7563 (1 year), 7123 (1.5 years), 6805 (2 years), 6316 (3 years), 5973 (4 years), 5706 (5 years), 5517 (6 years) and 5323 (7 years).