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. Author manuscript; available in PMC: 2020 Oct 14.
Published in final edited form as: J Thorac Oncol. 2019 Nov 18;15(2):231–247. doi: 10.1016/j.jtho.2019.10.023

Figure 3.

Figure 3.

Histopathologic features of SMARCA4-deficient composite tumors (case #20). (A, B) Hematoxylin and eosin section showing an abrupt transition from cohesive NSCC (right) to discohesive undifferentiated round cell/rhabdoid histology (left; Undif). Cell-to-cell cohesion is evident in NSCC component (right inset) compared with discohesion of round cell/rhabdoid component (left inset). The transition is accompanied by a sharp loss of SMARCA2 (D), keratins (E) and claudin-4 (F), superimposed on SMARCA4 deficiency in both components (C). SMARCA4 and SMARCA2 positive cells within undifferentiated component in C and D represent lymphocytes and stromal cells. Undif, undifferentiated.