Table 2.
Clinicopathological variables of patients undergoing limb salvage surgery vs. amputation
| Type of Surgery | p value | ||||||
|---|---|---|---|---|---|---|---|
| Limb Salvage Surgery | Amputation | Total | |||||
| n | % | n | % | n | % | ||
| Location | |||||||
| Lower Limb | 1536 | 82.8% | 506 | 86.2% | 2042 | 83.6% | 0.053 |
| Upper Limb | 319 | 17.2% | 81 | 13.8% | 400 | 16.4% | |
| Long vs Short Bone | |||||||
| Short Bone | 51 | 2.8% | 49 | 8.5% | 100 | 4.1% | p < 0.001 |
| Long Bone | 1789 | 97.2% | 527 | 91.5% | 2316 | 95.9% | |
| AJCC Clinical Stage | |||||||
| Stage 2A or 2B | 1509 | 81.3% | 438 | 74.6% | 1947 | 79.7% | p = 0.002 |
| Stage 3 | 63 | 3.4% | 25 | 4.3% | 88 | 3.6% | |
| Stage 4A or 4B | 283 | 15.3% | 124 | 21.1% | 407 | 16.7% | |
| Osteosarcoma Type | |||||||
| Osteosarcoma NOS | 1216 | 66.1% | 407 | 70.7% | 1623 | 67.2% | 0.059 |
| Chondro/Fibroblastic | 370 | 20.1% | 111 | 19.3% | 481 | 19.9% | |
| Telangiectatic | 78 | 4.2% | 24 | 4.2% | 102 | 4.2% | |
| Central | 108 | 5.9% | 24 | 4.2% | 132 | 5.5% | |
| Surface/Juxtacortical | 68 | 3.7% | 10 | 1.7% | 78 | 3.2% | |
| Tumor Size (cm); mean (95% CI) | 11.6 | 11.0–12.1 | 13.1 | 12.2–13.9 | 11.9 | 11.5–12.4 | 0.005 |
| < 8 cm | 547 | 30.6% | 132 | 23.0% | 679 | 28.7% | p < 0.001 |
| > 8 cm | 1242 | 69.4% | 442 | 77.0% | 1684 | 71.3% | |
| Presence of Metastases at Dx | |||||||
| No metastases | 1549 | 84.7% | 454 | 78.3% | 2003 | 83.2% | p < 0.001 |
| metastases | 279 | 15.3% | 126 | 21.7% | 405 | 16.8% | |
| Comorbidities at Dx | |||||||
| No comorbidities | 1714 | 92.4% | 520 | 88.6% | 2234 | 91.5% | 0.004 |
| 1 or more | 141 | 7.6% | 67 | 11.4% | 208 | 8.5% | |
| Received Adjuvant Chemotherapy | |||||||
| No | 81 | 4.4% | 62 | 10.6% | 143 | 5.9% | p < 0.001 |
| Yes | 1762 | 95.6% | 521 | 89.4% | 2283 | 94.1% | |
| Sequence of Adjuvant Treatment | |||||||
| Before | 558 | 37.3% | 170 | 38.7% | 728 | 37.6% | p < 0.001 |
| After | 162 | 10.8% | 88 | 20.0% | 250 | 12.9% | |
| Before+After | 777 | 51.9% | 181 | 41.2% | 958 | 49.5% | |
| Surgical Margins | |||||||
| Clear | 1617 | 93.7% | 541 | 96.6% | 2158 | 94.4% | p = 0.010 |
| Positive | 108 | 6.3% | 19 | 3.4% | 127 | 5.6% | |
| Unplanned Readmission After Surgery | |||||||
| No Unplanned Readmiss | 1727 | 96.2% | 548 | 95.6% | 2275 | 96.1% | 0.537 |
| Unplanned Readmission | 68 | 3.8% | 25 | 4.4% | 93 | 3.9% | |
| Inpatient Days after Surgery; mean (95% CI) | 6.7 | 6.3–7.1 | 6.3 | 5.6–7.1 | 6.6 | 6.3–7.1 | 0.3706 |
| Days from Dx to Surgery; mean (95% CI) | 96.1 | 94.1–98.1 | 91.8 | 87.6–96.1 | 95.1 | 93.3–96.9 | 0.049 |
| Days from Dx to Treatment Commencing; mean (95% CI) | 20.5 | 19.4–21.5 | 22.4 | 20.3–24.5 | 20.9 | 20.0–21.9 | 0.0796 |
| Total | 1855 | 75.96% | 587 | 24.04% | 2442 | 100% | |