Table 9.
Association of PFAAs exposure and infant TSH (adjusted results)
| Reference | Author Country Year |
Effect estimate | PFHxS | PFOS | PFOA | PFNA | PFDA | PFUnA | PFDoA |
|---|---|---|---|---|---|---|---|---|---|
| Maternal PFAAs concentrations obtained during 3rd trimester | |||||||||
| [38] |
Kato Japan 2016 |
Linear regression: Adjusted β (p value) | – | ↑: 0.177 (0.001) * | ↓: − 0.014 (0.801) | – | – | – | – |
| [44] |
Wang Taiwan 2014 |
Linear regression: Adjusted β (95% CI) |
↑: 0.493 (− 1.449, 2.434) |
↓: − 0.083 (− 0.292, 0.127) |
↓: − 0.498 (− 1.464, 0.468) |
↓: − 0.361 (− 0.955, 0.234) |
↓: −3.505 (−7.821, 0.812) |
↓: − 0.083 (− 0.232, 0.066) |
↓: − 1.539 (−6.582, 3.503) |
| [46] |
Yang China 2016 |
Spearmans partial correlation analysis. p < 0.05. | ↓: −0.034 | ↓: − 0.119 | ↓: − 0.057 | ↓: − 0.105 | ↓: − 0.145 | ↓: − 0.094 | ↑: 0.016 |
| [47] |
Xiao Faroe Island 2019 |
Percent change in thyroid hormone levels per doubling of PFAA concentrations (95% CI) | ↑: 11.5 (− 10.4, 39.0) | ↑: 39.7 (7.9, 80.9)* | ↑: 23.1 (1.9, 48.6)* | ↑: 53.3 (18.2, 99.0)* | ↑: 31.3 (2.2, 68.4)* | ↑: 7.6 (− 10.2, 28.8) | ↑: 0.2 (− 7.7, 8.7) |
| Cord blood serum/plasma PFAAs concentrations | |||||||||
| [48] |
Dufour Belgium 2018 |
Multivariate regression: Adjusted β (p value) | – | ↓: −0.028 (0.679) | ↓: −0.094 (0.196) | ↓: − 0.129 (0.064) | – | – | – |
| [49] |
Shah-Kulkarni Korea 2016 |
Linear regression: Adjusted β (95% CI) |
↓: − 1.09 (−2.60, 0.41) |
↓: −0.15 (− 1.03, 0.73) |
↓: − 0.79 (− 2.13, 0.55) |
↓: − 0.83 (− 1.95, 0.28) |
↓: − 1.01 (− 2.65, 0.62) |
↓: −0.62 (− 2.01, 0.76) |
↓: −1.29 (− 3.28, 0.69) |
| [51] |
Tsai Taiwan 2017 |
Linear regression: Adjusted β (95% CI) | – |
↑: 0.346 (0.101, 0.591)* |
↑: 0.059 (− 0.136, 0.254) |
↑: 0.045 (− 0.051, 0.142) |
– |
↑: 0.077 ( − 0.063, 0.216) |
– |
| [52] |
Aimuzi China 2019 |
Sparse partial least squares (SPLS): Adjusted β (95% CI) | # |
↓: − 0.012 (− 0.019,-0.005)* |
# |
↓: − 0.012 (− 0.019, − 0.005)* |
↓: −0.012 (− 0.02,-0.005)* |
↓: − 0.013 (− 0.021,-0.006)* |
↓: −0.013 (− 0.023,-0.006)* |
TSH (thyroid stimulating hormone), ↓ decreasing, ↑ increasing, bold format and star* indicate significant results P < 0.05, −: PFAAs not examined, # indicates association was not selected in SPLS model
PFAAs include: PFOS Perfluorooctane sulfonate, PFOA Perfluorooctanoate, PFHxS Perfluorohexane sulfonate, PFNA Perfluorononanoic acid, PFDA Perfluorodecanoic acid, PFUnA Perfluoroundecanoic acid, PFDoA Perfluorododecanoic acid