Table 2.
Univariate Cox analysis of overall survival∗
| Characteristic (selected) | Hazard ratio (95% CI) | P-value |
|---|---|---|
| Male (vs female) | 0.55 (0.18-1.67) | .29 |
| Smoking history (vs nonsmoker) | 1.20 (0.27-5.38) | .81 |
| Dysphagia at presentation (vs no dysphagia) | 1.15 (0.44-2.96) | .77 |
| Pretreatment feeding tube (vs no tube) | 3.11 (1.27-7.58) | .01 |
| T3 (vs T1-2 stage) | 2.35 (0.88-6.23) | .09 |
| Neoadjuvant (vs definitive intent) | 0.69 (0.09-5.26) | .72 |
| Completed concurrent chemotherapy (vs incomplete chemotherapy) | 0.30 (0.12-0.71) | <.01 |
| IMPT (vs IMRT) | 1.25 (0.52-3.03) | .62 |
| No treatment break during radiation therapy (vs treatment break) | 0.29 (0.11-0.81) | .02 |
| Completed radiation therapy (vs incomplete radiation therapy) | 0.16 (0.05-0.56) | <.01 |
| Surgery (vs no surgery) | 0.48 (0.21-1.14) | .09 |
| Primary radiation dose (per Gy) | 1.24 (1.04-1.48) | .02 |
| Boost dose (per Gy) | 1.17 (0.90-1.51) | .24 |
Abbreviations: CI = confidence interval; IMPT = intensity modulated proton beam therapy; IMRT = intensity modulated photon radiation therapy.
∗
Conducted with Cox regression analysis.