Table 3.
Pathologic findings and postoperative complications of IMPT and IMRT patients who underwent surgery
| Characteristic | IMPT (n = 15)∗ | IMRT (n = 18)∗ | Total (n = 33)∗ | P-value† |
|---|---|---|---|---|
| Surgical approach | .08 | |||
| Minimally invasive | 12 (80) | 18 (100) | 30 (91) | |
| Open | 3 (20) | 0 (0) | 3 (9) | |
| Pathologic stage‡ | ||||
| T stage | .06 | |||
| 0 | 6 (40) | 7 (39) | 13 (39) | |
| 1 | 3 (20) | 3 (17) | 6 (18) | |
| 2 | 4 (27) | 0 (0) | 4 (12) | |
| 3 | 2 (13) | 8 (44) | 10 (30) | |
| N stage | .04 | |||
| 0 | 12 (80) | 16 (89) | 28 (85) | |
| 1 | 3 (20) | 0 (0) | 3 (9) | |
| 2 | 0 (0) | 2 (11) | 2 (6) | |
| Margin status | .42 | |||
| Not reported | 2 (13) | 0 (0) | 2 (6) | |
| Negative | 12 (80) | 18 (100) | 30 (91) | |
| Margin | 1 (7) | 0 (0) | 1 (3) | |
| Invasion | >.99 | |||
| Not reported | 2 (13) | 0 (0) | 2 (6) | |
| None | 12 (80) | 16 (89) | 28 (85) | |
| Perineural | 1 (7) | 1 (6) | 2 (6) | |
| Lymphovascular | 0 (0) | 1 (6) | 1 (3) | |
| Pathologic complete response | 5 (33) | 7 (39) | 12 (36) | .42 |
| Downstaged status | 13 (87) | 13 (72) | 26 (79) | .20 |
| Postoperative complication | ||||
| Pneumonia | 2 (13) | 5 (28) | 7 (21) | .40 |
| Acute respiratory distress syndrome | 0 (0) | 3 (17) | 3 (9) | .23 |
| Esophageal stricture | 1 (7) | 2 (11) | 3 (9) | >.99 |
| Anastomotic leak | 3 (20) | 4 (22) | 7 (21) | >.99 |
| Anastomotic stricture | 4 (27) | 7 (39) | 11 (33) | .47 |
| Tracheoesophageal fistula | 2 (13) | 0 (0) | 2 (6) | .20 |
| Cardiac arrhythmia | 8 (53) | 3 (17) | 11 (33) | .06 |
Abbreviations: IMPT = intensity modulated proton beam therapy; IMRT = intensity modulated radiation therapy.
∗
Values are shown as n (%) of patients, unless stated otherwise.
†
Fisher exact test.
‡
Per the American Joint Committee on Cancer’s Cancer Staging Manual, 7th edition.