Table 4.
Grades 2 and 3 toxicities in IMPT and IMRT patients∗
| Toxicity | IMPT (n = 32)†,‡ |
IMRT (n = 32)†,‡ |
P-value§ | ||
|---|---|---|---|---|---|
| Grade 2 | Grade 3 | Grade 2 | Grade 3 | ||
| Esophagitis | 12 (38) | 1 (3) | 8 (25) | 0 (0) | >.99 |
| Dysphagia | 17 (53) | 9 (28) | 8 (25) | 4 (13) | .01 |
| Nausea | 8 (25) | 1 (3) | 4 (13) | 0 (0) | >.99 |
| Lymphopenia‖ | 5 (16) | 27 (84) | 4 (13) | 26 (81) | .65 |
| Vomiting | 1 (3) | 0 (0) | 0 (0) | 0 (0) | … |
| Radiation therapy−related dermatitis | 5 (16) | 0 (0) | 0 (0) | 0 (0) | … |
| Fatigue | 12 (38) | 0 (0) | 12 (38) | 0 (0) | … |
| Dehydration | 7 (22) | 0 (0) | 5 (16) | 1 (3) | >.99 |
| Anemia | 6 (19) | 0 (0) | 1 (3) | 1 (3) | … |
Abbreviations: IMPT = intensity modulated proton beam therapy; IMRT = intensity modulated photon radiation therapy.
Grade was assessed according to the Common Terminology Criteria for Adverse Events, version 4.
Values are shown as n (%) of patients, unless stated otherwise.
No grade 4 or 5 toxicities were reported, except for lymphopenia.
Grade 3 toxicities due to IMPT vs IMRT, determined with the Fisher exact test.
Grade 3 toxicity included grade ≥3 lymphopenia (6 IMPT and 9 IMRT patients had grade 4 lymphopenia). Lymphopenia toxicity was graded according to Common Terminology Criteria for Adverse Events, version 4: Grade 1, < lower limit of normal - 800/mm3; grade 2, <800-500/mm3; grade 3, <500-200/mm3; grade 4, <200/mm3.