Table 3.
Multivariate logistic regression analysis of factors associated with clinically significant PCa in patients with biopsy-naive and prior benign prostatic biopsy.
| Variables | Univariate |
Multivariate |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age | 1.08 (1.06-1.10) | <0.001 | 1.11 (1.08-1.13) | <0.001 |
| PSA | 1.13 (1.08-1.18) | <0.001 | 1.11 (1.00-1.24) | 0.062 |
| Prostate volume | 0.95 (0.94-0.96) | <0.001 | 0.95 (0.93-0.97) | <0.001 |
| PSAD | ||||
| <0.15 | - | - | - | - |
| 0.15-0.29 | 3.38 (2.51-4.55) | <0.001 | 1.86 (1.11-3.14) | 0.020 |
| ≥0.30 | 11.86 (7.41-18.97) | <0.001 | 3.19 (1.19-8.59) | 0.022 |
| PI-RADS | ||||
| 1 or | - | - | - | - |
| 3 | 2.05 (0.66-6.39) | 0.214 | 2.31 (0.68-7.89) | 0.182 |
| 4 or 5 | 18.39 (6.72-50.36) | <0.001 | 17.44 (5.81-52.37) | <0.001 |
Bold letters indicate significance (P < 0.05).
HR, hazard ratio; CI, confidence interval; PSAD, prostate-specific antigen density; PI-RADS v2, Prostate Imaging Reporting and Data System.